Brainō – sounds like something out of a cartoon or a comic book, doesn’t it? But no, it’s a real supplement made from real ingredients giving, say its makers Amazon Nutrition, real results.

So we thought something that sounded so bizarre could either be a complete con trick … or a stroke of genius. We looked into ‘Doctor-recommended’ Brainō to find out which it was.

Brainō Pros

  • You still get some benefits if you take just half a dose
  • No proprietary formula – you know exactly what you get
  • Some results happen straight away

Brainō Cons

  • Most results happen after a few weeks
  • No studies or clinical proof showing how well Brainō works
  • Frighteningly little information available about the company
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What You Need To Know About Brainō

You should feel a slight energy boost when first starting a course of Brainō, but it’s more formulated for long-term effects so it’s a case of taking the capsules for a long time before feeling the maximum effect. And that’s going to be expensive. We’d feel more comfortable with that idea if there was a discount for buying in bulk, but we couldn’t find one anywhere.

What Are The Side Effects Of Brainō?

In general, we discovered digestion problems like stomach cramps, more trips to the bathroom and looser stools. Looking a bit closer at some of the ingredients, though, we’ve found other potential side effects like dryness of the mouth, fatigue, rashes and a body odour that smells suspiciously of fish.

How Much Does Brainō Cost?

One month’s supply – that’s 120 capsules, four to be taken each day – costs $78.00. Add $7.00 if you’re buying direct from for shipping and handling, but if you’re buying through Amazon itself, there’s always free(ish) delivery with Amazon Prime.

We have to admit to being a bit puzzled by Amazon Nutrition’s website telling us the manufacturers suggested retail price is $129.00 before knocking the actual price down to $78.00. After all, they appear to be the manufacturers. That’s marketing for you.

Our Verdict On Brainō

Because the only indication of where anything to do with Amazon Nutrition is located just happens to be a phone number with a Las Vegas area code, we’d love to say what happens in Vegas stays in Vegas.

But we have no idea what goes on with Amazon Nutrition in the first place – whether they’re in Vegas or not – because they’re just far too coy about telling us about themselves.

As for Brainō itself, it would be reassuring to have some indication of how the combination of ingredients works, like, say, a clinical study or two showing some sort of improvement in mental function, but we couldn’t find anything like that. Anywhere.

And as for the identity of which doctor recommends Brainō in the first place, as we’re told on their very sparse website, we couldn’t find that anywhere, either.

There’s also some concern over the effectiveness of some of the ingredients, whether it’s the dosage, the effectiveness or even the potential side effects … so because of all these reasons we’re going to have to reject it. (We didn’t like the name much either.)

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Brainō Review

Brainō is marketed as a professional-strength brain supplement formula with multiple benefits on brain structure and function. The manufacturer is a company called Island Nutrition, but it’s sold online through

Brainō Facts

  • Amazon Nutrition boasts of being online since 1999, offering products such as wild salmon oil, probiotics and royal jelly supplements (about which they say, quote: “The following are sometimes claimed to be Health Benefits of Royal Jelly.” If that isn’t playing it safe, what is?).
  • And Amazon Nutrition is definitely playing it safe when it comes to details about where they’re physically located. There’s a phone number, and that’s all. Check the area code, and it seems they’re located in Las Vegas. As for any postal address – anywhere – well, there just isn’t one.
  • Brainō itself is said to increase circulation and oxygen to the head and boost some major neurotransmitters like Acetylcholine, Norepinephrine, Dopamine, or Serotonin.

Apparently it’s been ’trusted and continually improved since 1997, but here’s the problem: we looked through the first 20 pages of Google results for “Island Nutrition” in the hopes of finding out a bit more about the company and its product, but there was nothing in the way of solid information.

How to Take Brainō

You need to take 4 capsules daily, on an empty stomach, and then avoid protein for half an hour.

However, there’s always Brainō.com – a single-page website with one illustration and two not-so-obvious links. One goes to the Amazon sales page … and the other takes you which, according to their phone number’s area code, is based in Las Vegas. And that’s all we know about the company.

Brainō Concerns:

  • We know too little about the company for comfort.
  • One of the ingredients has many potential bad side effects.
  • Another ingredient is too low-dosage to have any effect at all.

The Amazon sales page urges readers to “Wipe Out Brain Fog and Supercharge Your Brain with Ultra-Premium Brain Support”, and that would be a very good reason for buying Brainō. Unfortunately, a few lines below that we also read “Premium ingredients work together to attack brain health from many angles”, which isn’t so confidence inspiring!

What Does Brainō Claim To Do?

Brainō is claimed to give you more energy without the kind of jitters you get with caffeine. As well as that, you should enjoy better focus, memory, clarity of thinking, creativity, mental alertness, healthy eyesight and hearing, together with a positive mood and overall well-being.

Brainō works by supporting oxygen supply to the brain, cerebral circulation, neurotransmitter quantity and activity, brain nerve structure and brain-cell regeneration.

But even though some of Brainō’s effects will be felt immediately, it will take weeks before users get the full benefit of this supplement.

Does Brainō Work?

Most of the ingredients in Brainō go some way to providing the effects claimed by the manufacturers, but there are exceptions.

  • Acetyl-l-Carnitine is in too small a dose to be recognised as effective
  • D/L-Phenylalanine is broken down by the body too fast to have a real effect
  • DMAE has been shown to have little effect on brain boosting

Other ingredients improve blood and oxygen flow to the brain and cause an improvement in neurotransmitter quality.

Some of those effects are noticeable straight away, while users will only notice other effects over the long term – it takes about a month to feel the full benefit of taking Brainō.

What Are The Ingredients of Brainō?

Brainō capsules are suitable for vegetarians.

  • Choline: Type of B vitamin found in egg yolks, which can help promote learning and overall cognitive performance.
  • Tyrosine: Amino acid which supports production of the brain energy neurotransmitter, noradrenaline. It can boost serotonin and dopamine and so help you feel more relaxed in yourself.
  • D/L-Phenylalanine (DLPA): Amino acid which supports production of neurotransmitters noradrenaline and dopamine. Unfortunately it’s not so easy to absorb – it’s broken down too quickly to have much of an effect.
  • PhosphatidylSerine: Type of fat that supports the structure of brain cells and has been seen to improve mood, memory, focus and reduce cognitive decline.
  • DMAE: Previously sold as a smart drug but has now been shown to have little effect when it comes to brain boosting, and could even cause some quite unpleasant side effects.
  • Acetyl-l-Carnitine: Supports energy production in cells, and is much better at increasing energy and speeding up the metabolism than actually promoting brain function. Studies show that you need a dosage of at least 500 mg for it to start having an effect, and it’s listed as only a 100 mg dose.
  • Taurine: The main ingredient of many energy drinks, doesn’t actually boost energy or, in this case, brain power. It does help with circulation, though, so it could support improved brain function that way.
  • Ginkgo Extract: Supports brain blood circulation and is reputed to help against dementia. But recent research shows that this might not be the case, and as far as improving cognitive function goes, some studies show that it may not be as effective as marketers would have us believe.
  • Bacopa Extract: Traditional Ayurvedic herb used to improve mental function in general, to improve anxiety and to boost memory. Many studies show that it helps to combat cognitive decline.
  • Club Moss: Traditional Chinese herb reported to inhibit breakdown of learning/memory neurotransmitter, acetylcholine, but those reports aren’t supported by a lot of studies.
  • Vinpocetine: Supports blood flow and oxygen to the brain, and is often used for tinnitus (ringing in the ears).

Does Brainō Have Any Side Effects?

We couldn’t find any listed on Amazon or Amazon Nutrition’s website, so we looked a little deeper into the individual ingredients themselves to see what we could find out about them, and this is what we discovered:

Choline can bring on headaches.

Tyrosine can cause digestive issues such as bloat, nausea, gas and heartburn.
DLPA can bring on anxiety, restlessness, rapid heartbeat, raised blood pressure and potential heart palpitations.

DMAE can cause constipation, urticaria, headaches, confusion, insomnia, depression and raised blood pressure. It could also make conditions like epilepsy, convulsions or bipolar disorder worse, too. It’s also linked, we’re told, with birth defects.

Acetyl-l-Carnitine can cause digestive problems, headaches, sleep problems, higher blood pressure, low blood sugar and can give your sweat and breath a fishy odour.

Taurine is a major ingredient of energy drinks, but little is really known about how taurine affects the brain. Energy drinks containing taurine has been seen to cause high blood pressure, strokes, seizures and heart disease.

Ginkgo thins the blood, and there’s the possibility of allergic reactions, headaches, dizziness and digestive problems.

Bacopa can bring on gastric problems including stomach cramp, nausea, more frequent visits to the bathroom and fatigue.

Chinese club moss contains chemicals which could affect the nervous system, and it’s possible it can have an adverse effect on people already suffering from asthma, blockages in the intestinal and urogenital tracts and those with heart, lung and digestive problems and diseases.

Vinpocetine can cause digestion problems, sleep disturbances, headaches, dizziness, nervousness and flushing of the face. It’s also known to slow down blood clotting.

If you are pregnant, nursing, using MAO inhibitors, have chronic high blood pressure or have a medical condition, consult a health professional before using this or any brain supplement.
Keep out of reach of children.

Are There Any Customer Reviews For Brainō?

It was pointless looking for reviews on, and fruitless looking for them on On Amazon itself, though, we found a whole 13 reviews, including:

I’m sorry they did not work for me at all in fact the only thing I noticed is a mild headache all day. I will continue to look for products that work if anybody has any suggestion please let me know.


The first day I took this product, I felt like my brain woke up, however, by the third day everything was back to normal.

And just…


Does Brainō Offer a Money-Back Guarantee?

Apparently so – on their Amazon sales page they do say, “we guarantee results”! But how to follow up on that guarantee is something we haven’t managed to find yet, on Amazon, at least.

But there is a return policy in place on they accept returns within 30 days of purchase and refund 100% of the purchase price less S&H, but you need to contact them first. Since 1999, they say, there have only been a “handful” of returns.

Where Can I Buy Brainō?

It’s available through Amazon, and many websites give details about the product and then give you a link straight to the Amazon sales page.

And, of course, you could always order through the website.

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1.3 out of 5
Editor's Rating
  • Effectiveness
  • Safety
  • Price / Guarantee
The most popular consumer choice in 2021 is OmniMind

Containing ingredients that have been clinically tested and boasting a 30-day money-back guarantee, OmniMind is quickly rising to the top of the nootropic world.

Find out why people are choosing OmniMind to achieve advanced brain performance, and why it's our editor's top pick.

Read the Nootropic Watchdog OmniMind review here.

Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

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