Stress is a common modern day problem that affects all of us to some degree. If like many people you lie awake worrying at night, can’t relax and find social situations freak you out, could a supplement called Tranquilene help? We take an in-depth look to find out more about this nootropic supplement.

Tranquilene comes from Tranquillity Labs a US company based in Medford, Massachusetts. The company have an A+ better business rating and according to the product information Tranquilene, is manufactured in the USA in accordance with GMP.

Tranquilene Pros

  • Positive customer feedback
  • 60-day guarantee

Tranquilene Cons

  • May cause side effects
  • Autoship program
  • Incomplete ingredients profile
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What You Need To Know About Tranquilene

Tranquilene is a nootropic supplement that is marketed as a way to reduce anxiety and calm you down. It contains herbal ingredients that may have this effect but many customers have complained that it has caused them to have panic attacks. Tranquilene is manufactured in the USA and complies with GMP so should be relatively safe. However you are encouraged to sign up to autoship and take this supplement on a permanent basis. We do not advise this for health or financial reasons.

What Are The Side Effects Of Tranquilene?

Side effects may includ: sleepiness, anxiety/panic attacks – many people have mentioned this particular effect, grogginess, headaches, vomiting, diarrhoea or chest pains.

How Much Does Tranquilene Cost?

If you buy from the official website, you have to sign up to auto billing. This is where fresh supplies are delivered to your home each month and your credit or debit card billed automatically. This option costs $34.95 a month (one bottle of 60 capsules or 30 servings).

You can also buy Tranquilene via Amazon. This is the more straightforward option as you can choose to buy just one bottle with no strings attached. One bottle of 60 capsules (30 servings) costs $39.94 via Amazon.

Our Verdict On Tranquilene

We like some aspects of Tranquilene. This supplement is popular with many customers and contains ingredients that may have a calming effect. We like that it is made in the USA and that the company, Tranquillity Labs has an A+ BBB rating. We like that it offers a money-back guarantee.

However, many people have mentioned that Tranquilene does sometimes cause panic attacks and other side effects and the herbal ingredients may not be safe for everyone to use. There has been little clinical testing into their various effects and in addition, this formula has probably never been fully evaluated. Does it really work together? The simple answer is that we just don’t know.

In addition we are not happy that the only way to buy this supplement via the official website is by signing up to autoship. Although the company claims to let you cancel this agreement within 48 hours, this may not be as straightforward as it appears. In our experience these types of agreement can be hard to get out of.

In addition, is it really a good idea to take a supplement to calm you down on a permanent basis? If you have ongoing anxiety problems surely it is better to take some trained advice from a mental health professional.

Tranquilene may be worth a try for occasional use but in our opinion, this supplement just is not safe for everyone to use.

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Tranquilene Review

Stress is a modern problem that affects most of us. Money issues work, health, relationships, kids, grandkids … the pressure never really stops and although some stress is good for us because it keeps us on our toes and interested in life, too much stress is detrimental to health. These days many people are taking to mindfulness as a way to de-stress but others use exercise, alcohol and even prescription drugs when things get too bad.

Tranquilene is a supplement that according to the advertising is designed to reduce stress levels. This natural supplement contains amino acids and nutrients to help increase your serotonin and GABA levels, two brain chemicals that are important for mood, mental performance and happiness.

Tranquilene Facts

  • Each bottle contains 60 capsules.
  • You are encouraged to take on a permanent basis.
  • Made in the USA in compliance with GMP.

The supplement contains Vitamin B Complex – the entire range of B vitamins all of which are important to healthy brain function and mental performance. It also contains a blend of herbal ingredients such as Ashwaganda, Bacopa Monnieri and Passionflower extract which all come with some evidence that the natural chemicals contained in the extracts may have a calming effect. Many of these plants such as passionflower have long been used in traditional medicine for this purpose.

Other ingredients include L-theanine – an amino acid found exclusively in tea and the component that gives tea its energising yet calming effects. It also contains synthetic GABA (gamma-Aminobutyric acid). In the human brain GABA is the chief inhibitory neurotransmitter which means it is important for regulating the nervous system and neuronal excitability.

How to Take Tranquilene

Recommended dosage is two capsules taken with water, either both in the morning, or one in the morning and one in the afternoon – as you see fit. For maximum effectiveness, it is recommended that you take it 20 to 30 minutes before food.

The remaining ingredients included tryptophan an essential amino acid which means it has to be ingested by diet as the body cannot manufacture it. Tryptophan is important because the body converts this into another chemical called 5HTP (5-hydroxy-tryptophan) which in turn then changes to serotonin, the brains feel good chemical.

Overall Tranquilene looks as if it may have a calming effect although it is important to remember that many of the herbal ingredients have not been clinically tested. In addition the ingredients information is lacking in any real details. All the herbals are combined in a proprietary blend so it is impossible to judge strength and know whether amounts correspond to the limited clinical investigation for the ingredients.

Tranquilene Concerns:

  • The side effects: many customers have experienced panic attacks and other side effects.
  • The autoship agreement. Will the company really cancel the agreement within 48 hours?
  • Is it sensible to take any nootropic supplement full time? We think you should seek medical opinion rather than turn to an OTC supplement.

Tranquilene comes from a US company called Tranquillity Labs based in Medford, Massachusetts. The company have BBB A + rating which is encouraging and we have been unable to find any customer complaints associated with this company.

Tranquillity Labs has been in operation for the past 6 years and sell a range of supplements, many based on Eastern-style medicine. According to the product information, Tranquilene contains ingredients such as Ashwaganda which are popular in China but the customer can be reassured that Tranquilene is manufactured in the USA and conforms to full-safety standards (GMP).

One disturbing and major point about Tranquilene is that if you buy from the official website, you have to sign up to autoship. This is where fresh supplies are delivered automatically to your door and your bank card billed accordingly. These agreements can be hard to cancel and although the product information claims you can cancel in just 48 hours by email, we have no way of knowing whether this is true. We tried to contact customer services but did not get an answer.

In addition, is it really a good idea to rely on any type of medication on a permanent basis, as it seems you are encouraged to do with Tranquilene?

What Does Tranquilene Claim To Do?

According to the product information,

Tranquilene has been scientifically formulated to reduce stress levels using the latest advances in the fields of psychology, nutrition, herbal medicine and neuroscience. Tranquilene is the only all-natural supplements that offers a complete set of building – block nutrients for serotonin and GABA – the two most important brain chemicals for keeping you calm, relaxed and focused. Unlike many of the hard drugs pharmaceutical companies push, Tranquilene is all-natural and non-habit-forming.

You are encouraged to take Tranquilene long term by signing up to autoship.

If you are suffering from persistent worry, nervousness or stress you can find Total Calm with the Tranquilene Auto–Ship Program, a monthly shipment of our powerful, proprietary supplement. With the Tranquilene Auto–Ship program you only need to sign up once to make sure you don’t miss a dose.

Does Tranquilene Work?

Some customers swear by Tranquilene and state that it improves anxiety, helps with stress and helps prevent panic attacks. However it is important to remember that the ingredients in the formula have not been clinically proven and the formula has not been clinically tested. In addition it is unknown whether the ingredients in Tranquilene conform to what little clinical testing there has been on the individual ingredients. Some customers have reported zero effects and some people have suffered from side effects. We are all different and reactions to herbal ingredients can vary.

This supplement may be worth a try but we would not recommend you sign up to auto ship which may be hard to cancel. More importantly, if you have a permanent condition that causes anxiety or panic attacks you should seek some professional advice rather than take an OTC supplement long-term.

What Are The Ingredients of Tranquilene?

Tranquilene do not widely publicise the ingredients of this supplement, but we managed to track down a bottle and look at the label. There is not much information because the ingredients are combined in a proprietary blend.
Serving size is equal to two capsules.

Proprietary blend (976 mg)

  • Passionflower: Passiflora incarnata was used traditionally in the Americas and later in Europe as a calming herb for anxiety, insomnia, seizures, and hysteria. It is still used today to treat anxiety and insomnia. Scientists believe passionflower works by increasing levels of a chemical called gamma aminobutyric acid (GABA) in the brain. GABA lowers the activity of some brain cells, making you feel more relaxed. Serving size in capsule form has not really been studied.
  • GABA: In the human brain GABA is the chief inhibitory neurotransmitter which means it is important for regulating the nervous system and not letting neuronal excitability get out of hand. It works by blocking brain signals (neurotransmissions). Taking in supplement form may relieve anxiety and improve mood but it requires further evidence.
  • L-Tryptophan: Amino acid present in many foods including turkey and Brazil nuts. Once in the body, it eventually converts to serotonin, the brains feel good chemical. Although it is safe when ingested in food, supplements can cause side effects and are considered unsafe.
  • Ashwaganda: Ayervardic (Indian traditional medicine) medical plant that my help reduce stress. It is used as an Adaptogen – a general pick me up or tonic and it may lower blood pressure and have a calming effect. The form in this supplement is a branded Ashwaganda supplement called KSM66. It has been clinically tested and found to reduce stress levels, reducing serum cortisol.
  • Bacopa Monnieri: Water hyssop plant that may help reduce anxiety and improve memory function. It has an effect upon dopamine and serotonin systems and it also may help the formation of neurons. Usual serving size is 300 mg and it can take up to 12 weeks for any effects to be noticed.
  • L-Theanine: Amino acid found only in the tea plant and the part that gives tea its unique, energising yet relaxing effects. L Theanine increases the activity of GABA, a neurotransmitter (natural messenger in the brain) that promotes relaxation and helps keep your nerves calm. L-theanine also stimulates the release of dopamine, a neurotransmitter responsible for confidence and a sense of well-being.
  • Green Tea Extract: Green tea is rich in antioxidants and in particular a type of molecule called epigallocatechin gallate. It has numerous health benefits.

Tranquilene also includes vitamins and minerals, important for general health as well as brain health:

  • Calcium (21 mg)
  • Vitamin b1 (300 mcg)
  • Vitamin B3 (20 mg)
  • Vitamin B6 (15 mg)
  • Vitamin B12 (10 mcg)
  • Vitamin B5 (15 mg)
  • Vitamin D3 (600 IU)
  • Magnesium citrate (15 mg)

Does Tranquilene Have Any Side Effects?

Some of the ingredients contained in this supplement are known for side effects. In addition some customers have experienced reactions to taking this supplement. These are typical side effects from the various ingredients and may include:

  • Sleepiness
  • Anxiety
  • Panic attack
  • Grogginess
  • Headaches
  • Vomiting
  • Diarrhoea
  • Chest pain

Not suitable for individuals under 18. Avoid if you are pregnant or breast feeding. Consult your physician before using if you have an underlying medical condition (including mental health issue) or are taking prescription medication. Some of the ingredients could cause interactions.

Are There Any Customer Reviews For Tranquilene?

There are many customer reviews for Tranquilene on Amazon alone and there is a wide range of opinion.

I have found Tranquilene to be a very useful product; I run a small farming business and never seem to get it all done. There is constant stress in meeting many obligations, deadlines, jobs, and chores. My nights have, in the past, been when my mind truly went to work. Today by taking this product regularly, my nights are now spent getting the sleep I need to be effective and present.

I suffer from panic disorder and this product is all I need to get out the door and on my way.

Works good for me… I don’t take all the pills at once because it makes me kind of sleeping… I take one, wait about 30 minutes then take another one… I have only taken them when I knew I was going to be in a highly anxiety place… I have not took them yet when I was having a huge anxiety attack.

This product doesn’t work and I feel no difference.

This did not work for me … in fact; it sent me into a panic attack! I only took one dose (2 capsules).

Did not work at all, gave me a panic attack.

Does Tranquilene Offer a Money-Back Guarantee?

There is a money-back guarantee. Here’s what the company have to say about it:

If you are unsatisfied for any reason, you may return the product within 60 days for a full refund of the purchase price.

Where Can I Buy Tranquilene?

Tranquilene is only available to buy online. You can buy it directly from the official Tranquilene website and it is also on sale via Amazon. Customers outside the USA can buy via the official website.


2.5 out of 5
Editor's Rating
  • Effectiveness
  • Safety
  • Price / Guarantee
The most popular consumer choice in 2021 is OmniMind

Containing ingredients that have been clinically tested and boasting a 30-day money-back guarantee, OmniMind is quickly rising to the top of the nootropic world.

Find out why people are choosing OmniMind to achieve advanced brain performance, and why it's our editor's top pick.

Read the Nootropic Watchdog OmniMind review here.

Disclaimer: Our reviews and investigations are based on extensive research from the information publicly available to us and consumers at the time of first publishing the post. Information is based on our personal opinion and whilst we endeavour to ensure information is up-to-date, manufacturers do from time to time change their products and future research may disagree with our findings. If you feel any of the information is inaccurate, please contact us and we will review the information provided.

Have Your Say

1 comment on 'Tranquilene'

  1. I’ve read so many great reviews of Tranqulene….and here I find it can give people panic attacks? What ingredients in tranqulene would even give one panic attack. Can you please explain? Thank you!

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